Also, our findings significantly suggest that diclofenac and other NSAIDs may decrease the effectiveness of Xyrem used in the treatment of narcolepsy.”Īdditional investigators include first author, UB alumna and former graduate student in Morris’ lab Vivian Rodriguez‐Cruz, PhD, research scientist at Eli Lilly and Company and Tianjing Ren, PhD, postdoctoral researcher in the UB School of Pharmacy and Pharmaceutical Sciences.Ĭommonly sold under the brand name Voltaren, diclofenac is prescribed to treat pain and inflammation. In this research, we identified the NSAID diclofenac as a MCT1 inhibitor and demonstrated its effectiveness as a potential antidote for GHB overdose. My laboratory has identified MCT1 inhibitors as a treatment strategy to prevent death after GHB overdoses. “Current treatment of GHB overdose is limited to supportive care. The abuse of GHB – known as Fantasy, Liquid Ecstasy and G – carries the risk of severe adverse effects including sedation, respiratory depression, hypothermia, coma and death,” says Marilyn Morris, PhD, SUNY Distinguished Professor and chair of the Department of Pharmaceutical Sciences in the UB School of Pharmacy and Pharmaceutical Sciences. “The therapeutic utility of GHB in the treatment of narcolepsy has been overshadowed by its high prevalence of abuse. There are currently no approved antidotes for GHB overdose. At high doses, the drug can cause amnesia, drowsiness and depressed breathing. However, GHB prescriptions are limited due to its high potential for abuse as a club and date-rape drug. GHB is approved for a number of clinical uses, including the treatment of narcolepsy, a chronic sleep disorder, and alcoholism. Previous studies completed by the UB researchers found that the NSAIDs ibuprofen and ketoprofen also affected the movement of GHB in the body. The study, completed in animal models, was published in Biopharmaceutics & Drug Disposition. The research found that treatment with diclofenac after taking GHB led to decreased concentrations of GHB in the brain and an improved respiration. – Diclofenac and other non‐steroidal anti‐inflammatory drugs (NSAIDs) may limit the passage of gamma hydroxybutyric acid (a narcolepsy medication and illicit party drug commonly known as GHB) to the brain, decreasing the potential for fatal overdose, according to a University at Buffalo study.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |